BME 100. Introduction to Biomedical Engineering for Summer Scholars. 3 Credit Hours.

This introductory course is designed to expose high school students to biomedic al engineering. The program is designed for the exemplary high school student interested in applied mathematics and science. The students will be provided w ith an understanding and some hands-on experience on topics relative to the dis cipline of Biomedical Engineering. The course content changes throughout the 3 -week duration and includes topics on lasers, medical imaging, biomaterials, bi oelectricity and biomechanics. The students will be able to understand the cah llenges associated with the desing, testing and FDA clearance of biomedical dev ices and the importance of the scientific methods in engineering.. The laborato ry and field trip experiences will deal with the desingn and thesting of a bio electric device. Summer Scholar Students only.
Components: LEC.
Grading: GRD.
Typically Offered: Summer.

BME 111. Introduction to Engineering I. 3 Credit Hours.

Use of engineering tools for problem solving are discussed. Topics include the use of computer techniques for data acquisition, analysis, presentation, software design, computer aided drafting, and development of design skills through several design and building competitions. Introduction to professional ethics and intellectual property rights, the use of MATLAB, AutoCAD, and programming in C++.
Components: LEC.
Grading: GRD.
Typically Offered: Fall & Spring.

BME 112. Introduction to Engineering II. 3 Credit Hours.

Introduction to biomedical engineering analysis, design, and manufacturing processes. Ethics, regulatory factors, and biomedical engineering design tools (mechanical, electrical and computer tools) are introduced. Hands on experience is provided through a project in which the students design, assemble, program, and test biomedical devices.
Prerequisite: BME 111.
Components: LEC.
Grading: GRD.
Typically Offered: Fall & Spring.

BME 211. Introduction to programming for Biomedical Engineers. 3 Credit Hours.

This course will provide a comprehensive introduction to programming using MATLAB. The students will learn MATLAB functions for importing, analyzing, visualizing and exporting data, numerical computation, modeling and solving biomedical engineering problems.
Components: LEC.
Grading: GRD.
Typically Offered: Fall & Spring.

BME 265. Medical Systems Physiology. 3 Credit Hours.

Human physiological processes from a bioengineering and medical point of view. Pertinent aspects of anatomy, biophysics, biochemistry, and disease mechanisms are also included.
Co-requisite: BIL 150 And BIL 151 And CHM 112.
Components: LEC.
Grading: GRD.
Typically Offered: Spring.

BME 266. Human Physiology Laboratory. 1 Credit Hour.

This course provides a series of laboratory experiments to assist students to learnhuman physiology through noninvasive measurements by using the PowerlabPhysiology Data Acquisition station. Following introductory lectures in the lab, students will assemble measurement probes, connect different devices, collect data under normal and stimulating conditions, and perform data analysis. Lab report is required for each experiment.
Prerequisite: Or Corequisite: BME 265.
Components: LEC.
Grading: GRD.
Typically Offered: Fall & Spring.

BME 302. Cellular Engineering. 3 Credit Hours.

Cellular engineering addresses issues related to understanding and manipulating cell structure-function relationships. This course is intended to bridge between cell biologists and engineers, to understand quantitatively cell biological aspects. Central to biomaterial and tissue engineering is our use of cells and our understanding of their interactions with their environment. It is important to understand how cells respond to external signals from their substrata or their milieu, how they move, and what they need in order to perform their desired function. Students are provided with an introduction to engineering principles and modeling at the cellular level. Of particular interest are cytomechanics, receptor/ligand binding, genetic engineering, enzyme kinetics, and metabolic pathway engineering.
Components: LEC.
Grading: GRD.
Typically Offered: Spring.

BME 305. Biomedical Technology. 3 Credit Hours.

Non-mathematical introduction to technical and clinical aspects of biomedical e ngineering. Biomedical signals and instrumentation, sensors, transducers, physi ological measurements, laboratory instrumentation, implants, cardiac assist dev ices, radiology, ultrasound, CT, MRI, transmission, and scanning electron microscopy. Field trips to clinical and research laboratories are included. Open only to non-BME students.
Prerequisite: BIL 150 and CHM 111.
Components: LEC.
Grading: GRD.
Typically Offered: Spring.

BME 310. Mathematical Analysis in Biomedical Engineering. 3 Credit Hours.

Mathematical modeling of physiological and other biomedical engineering systems and devices. Basic engineering principles and mathematical tools are covered f or rigorous understanding of physiological regulation and control in biosystems .
Prerequisite: MTH 311.
Components: LEC.
Grading: GRD.
Typically Offered: Fall & Spring.

BME 311. MATLAB for Biomedical Engineers. 1 Credit Hour.

Laboratory course for applications of Matlab in biomedical engineering. Upon t he completion of this course, students will be able to write Matlab scripts to solve engineering problems and perform basic analysis and processing of biomedi cal signals. The course includes Matlab programming environment; Metlab variab les; FOR, IF and WHILE statements, plotting and advance graphics, user defined functions, symbolic computation, data file management and graphical user interf aces. The course concludes with a final project focused in biomedical applicat ions.
Prerequisites: ECE 118, BME 310. Or Corequisite: BME 310.
Components: LAB.
Grading: GRD.
Typically Offered: Fall & Spring.

BME 312. Biomedical Statistics and Data Analysis. 3 Credit Hours.

The course will provide a comprehensive introduction to biostatistical models and methods, with applications in clinical trials research, observational studies, physiology, genomics and public health. Various examples will be solved using MATLAB and the results will be compared and discussed. A brief introduction to R will be provided.
Prerequisite: BME 211.
Components: LEC.
Grading: GRD.
Typically Offered: Fall.

BME 320. The Evolution of Technology. 3 Credit Hours.

Organized and taught by an intedisciplinary team, this innovative course is designed for juniors and seniors. An experimental elective, the course uses multimedia to explore the ways in which innovation is driven by the needs of society and individuals, and nurtured by improvements in tools and production. Five broad subject areas will receive special attention: survival, communication, transportation, entertainment and medicine.
Components: LEC.
Grading: GRD.
Typically Offered: Spring.

BME 330. Foundations of Medical Imaging. 3 Credit Hours.

Physical and biological principles of medical imaging, including ultrasound, X-ray, nuclear, magnetic resonance, electrical impedance and optical imaging. Propagation and interaction of ultrasonic waves, light waves, X-ray photons, and nuclear radiation in hard and soft biological tissue. Corequisite: BME 310.
Prerequisite: BME 310. Or Corequisite: BME 310.
Components: LEC.
Grading: GRD.
Typically Offered: Fall.

BME 335. Biomaterials. 3 Credit Hours.

Introduction to the field of Biomaterials. Review of materials science for four main types of biomaterials: ceramics, metals, polymers, and composites. Lectures on special topics given by guest lecturers who are active in their specific areas, under supervision of the instructor.
Components: LEC.
Grading: GRD.
Typically Offered: Fall & Spring.

BME 375. Fundamentals of Biomechanics. 3 Credit Hours.

Application of solid and fluid mechanics to describe the mechanical behavior of human motion, mechanical behavior of soft and hard biological tissues, cells and biofluids. Review of fundamental concepts and techniques of mechanics (stress, strain, constitutive relations). Focus on mechanical properties of specific tissues, including tendon, skin, smooth muscle, heart muscle, cartilage, and bone. Cellular and biofluid mechanics will be presented.
Components: LEC.
Grading: GRD.
Typically Offered: Fall & Spring.

BME 395. Undergraduate Research in Biomedical Engineering. 1-3 Credit Hours.

Research and/or design projects consisting of an individual investigation of cu rrent problems. Offered by special arrangement only.
Components: THI.
Grading: GRD.
Typically Offered: Fall, Spring, & Summer.

BME 399. Cooperative Education. 1 Credit Hour.

Practical application of classroom theory through alternating semester or summe r employment with firms offering positions consistent with the student's field of study. May be repeated.
Components: THI.
Grading: GRD.
Typically Offered: Fall, Spring, & Summer.

BME 401. Biomedical Design. 3 Credit Hours.

Planning Phase of an individual or group project for seniors, to be taken during the penultimate semester to graduation.
Components: LEC.
Grading: GRD.
Typically Offered: Fall & Spring.

BME 402. Senior Design I. 1-2 Credit Hours.

Completion of individual or group project for seniors, to be taken during the final semester before graduation. A total of 3 credits in this 401-402 sequence.
Prerequisite: BME 401.
Components: LEC.
Grading: GRD.
Typically Offered: Fall & Spring.

BME 403. Senior Design II. 1 Credit Hour.

Completion of individual or group project for seniors, to be taken during the f inal semester before graduation.
Prerequisite: BME 402.
Components: LEC.
Grading: GRD.
Typically Offered: Fall & Spring.

BME 440. Biomedical Measurements. 4.00 Credit Hours.

Introduction to the principles of measurements in physiological and biological systems, as well as a discussion of measurable parameters, transducers, sensors, signal conditioning, and processing. Laboratory experiments are conducted in parallel with the course.
Prerequisite: BIL 150 and BIL 151.
Components: LEC.
Grading: GRD.
Typically Offered: Fall & Spring.

BME 450. Biomedical Transport Phenomena. 3 Credit Hours.

Fundamentals of transport phenomena in biological systems including diffusion, osmosis, convection, electrophoresis, and transport with binding. Applications to cell electrophysiology and drug delivery. Introduction to physiological fluid flow in tissues.
Components: LEC.
Grading: GRD.
Typically Offered: Fall & Spring.

BME 460. Introduction to Physiological Fluid Mechanics. 3 Credit Hours.

The role of transport processes in biological systems, mathematical modeling of physiological fluid transport, conservation of mass and momentum rheology of blood flow in large and small vessels, approximation methods for the analysis of complex physiological flow, fluid flow in the circulation and tissue. Basic engineering principles and mathematical tools are covered for rigorous understanding of physiological fluid flow.
Prerequisite: BME 310 and PHY 206.
Components: LEC.
Grading: GRD.
Typically Offered: Spring.

BME 470. Biomedical Signal Analysis. 3 Credit Hours.

Time and frequency description, analysis and processing of biophysical and physiological signals. This course covers analytical and computational tools for measuring, manipulating and interpreting signals fundamental to biomedical engineering. Fourier analysis, Fourier transform, data acquisition, averaging, digital filter design, discrete Fourier transform, correlation, convolution, coherence are discussed.
Prerequisite: BME 311. Or Requisite: Permission of Instructor.
Components: LEC.
Grading: GRD.
Typically Offered: Fall & Spring.

BME 480. Biomedical Instrumentation. 3 Credit Hours.

Analysis and design of systems and electronic circuits in biomedical instrumentation including modeling and simulation of dynamic measurement systems and implementation of analog signal processing. The functional principles, operation, clinical context and technological trends of medical instrumentation systems used in clinical and research applications will be discussed.
Prerequisite: BME 440.
Components: LEC.
Grading: GRD.
Typically Offered: Fall & Spring.

BME 501. Unified Medical Sciences I. 3 Credit Hours.

Treatment of the basic biological and medical elements in physiological systems. The anatomy, physiology, biophysics, biochemistry and certain aspects of clinical medicine are unified with an emphasis on cellular and subcellular systems. Not open to BME undergraduates.
Components: LEC.
Grading: GRD.
Typically Offered: Fall.

BME 502. Unified Medical Sciences II. 3 Credit Hours.

Treatment of the basic biological and medical elements in physiological systems . The anatomy, physiology, biophysics, biochemistry, and certain aspects of clinical medicine are unified with an emphasis on cardiovascular, renal, digestive, endocrine, and reproductive systems. Not open to BME undergraduates.
Components: LEC.
Grading: GRD.
Typically Offered: Fall.

BME 503. Unified Medical Science III. 3 Credit Hours.

Treatment of the basic biological and medical elements in physiological systems. The anatomy, physiology, biophysics, biochemistry, and certain aspects of clinical medicine are unified with an emphasis on neural, sensory, and muscular systems. Not open to BME undergraduates.
Components: LEC.
Grading: GRD.
Typically Offered: Spring.

BME 506. Computer Aided Design in Biomedical Engineering. 1 Credit Hour.

Laboratory course for computer based two and three dimensional drawing and design based on ProEngineer. Parametric design, parts, features, assemblies for complex modeling. Applications in biomedical engineering design.
Components: LAB.
Grading: GRD.
Typically Offered: Spring.

BME 507. LabView Applications for Biomedical Engineering. 1 Credit Hour.

Laboratory course for computer based instrumentation and design based on Labvie w. Virtual instrumentation, data acquisition and display, GPIB instrument contr ol, biomedical applications in biosignal recording, and monitoring are discussed.
Components: LAB.
Grading: GRD.
Typically Offered: Spring.

BME 510. Introduction to Medical Robotics. 3 Credit Hours.

This course will discuss the basic principles of robotics and focus on its medical applications. The course integrates previously learned math, programming and imaging knowledge into an application platform to enable students to understand fundamentals of robotics methods in biology and medicine and to train students to build a robotics prototype through hands-on projects.
Prerequisite: BME 310, BME 311, and BME 330.
Components: LEC.
Grading: GRD.
Typically Offered: Offered by Announcement Only.

BME 512. Regulatory Control of Biomedical Devices. 3 Credit Hours.

Regulatory agencies and requirements, Food and Drug Administration, 510(k) and premarket approval (PMA), international regulatory requirements, ISO 9000 series, CE, UL, product and process validation, quality engineering, quality improvement programs, rapid prototyping, packaging and sterilization, and project management are discussed.
Components: LEC.
Grading: GRD.
Typically Offered: Spring.

BME 520. Medical Imaging System. 3 Credit Hours.

Engineering and scientific principles of medical imaging systems. The concepts of instrumentation and diagnostic applications of different techniques and syst ems are presented. Demonstrations or exhibitions of medical systems are given i n the visits to clinic and research laboratories. Topics include digital image and image processing fundamentals, radiographic (X-ray, CT), magnetic resonance (MRI) and radio-isotopic (PET) systems, and associated image reconstruction techniques. Basic concepts and simulation of imaging systems are emphasized.
Prerequisite: ECE 118 and ECE 201. Corequisite: BME 470 or equivalent.
Components: LEC.
Grading: GRD.
Typically Offered: Fall.

BME 521. Medical Imaging Applications. 3 Credit Hours.

Medical applications of imaging systems and image processing techniques. Topics include image fundamentals (resolution, format, and storage), image processing fundamentals (transformation, compression, enhancement, segmentation, registration, and reconstruction), and image analysis fundamentals (calibration, quantification, correlation, linearity and depiction). Course includes dedicated computer laboratory projects and demonstrations given in clinical and research laboratories at the medical campus.Corequisite: BME 570 or equivalent.
Prerequisite: ECE 118 and ECE 201. Corequisite: BME 470 or equivalent.
Components: LEC.
Grading: GRD.
Typically Offered: Offered by Announcement Only.

BME 522. Scanning Electron Microscopy for Engineers. 3 Credit Hours.

Physics of transmission and scanning electron microscopy including x-rayspectroscopic analysis. Students will learn to independently operate and use the SEM for imaging in its role in research and engineering. Each student will be responsible for several imaging assignments and an independent research project related to their field of interest.
Components: LEC.
Grading: GRD.
Typically Offered: Spring.

BME 525. Special Problems. 1-3 Credit Hours.

Research and/or design projects consisting of an individual investigation of current problems. Offered by special arrangement only.
Components: THI.
Grading: GRD.
Typically Offered: Fall, Spring, & Summer.

BME 526. Special Problems. 1-3 Credit Hours.

Research and/or design projects consisting of an individual investigation of current problems. Offered by special arrangement only.
Components: LEC.
Grading: GRD.
Typically Offered: Fall & Spring.

BME 531. Technical Entrepreneurship I. 1 Credit Hour.

The first half of a two-semester sequence that simulates the work of a product development team to gain experience in technical entrepreneurship. The students propose product ideas, assess those collectively, select a few, form teams, define the product, and perform market analysis. The course is concluded with a business and technical development plan for the team's project. Lectures are presented on a variety of entrepreneurial topics.
Components: LEC.
Grading: GRD.
Typically Offered: Fall & Spring.

BME 532. Technical Entrepreneurship II. 2 Credit Hours.

The second half of a two-semester sequence that simulates the work of a product development team to gain experience in technical entrepreneurship. The students complete the development of a working prototype and refine their marketing and business plan based on experience gained during the development phase. Lectures are presented on relevant entrepreneurial topics.
Components: LEC.
Grading: GRD.
Typically Offered: Fall & Spring.

BME 535. Advanced Biomaterials. 3 Credit Hours.

Applications of biomaterials in different tissue and organ systems. Relationshi p between physical and chemical structure of materials and biological system re sponse are discussed as well as choosing, fabricating, and modifying materials for specific biomedical applications.
Components: LEC.
Grading: GRD.
Typically Offered: Offered by Announcement Only.

BME 540. Microcomputer-Based Medical Instrumentation. 3 Credit Hours.

Principles and design of microcomputer-based biomedical instruments, analog and digital signal conversion, microcomputer hardware and software design, algorithm development for medical applications, medical signal processing with microcomputers, software safety in life support systems, and current applications are discussed.
Components: LEC.
Grading: GRD.
Typically Offered: Offered by Announcement Only.

BME 541. Medical Electronic Systems Laboratory. 2 Credit Hours.

Laboratory course for BME 540. Design of medical instruments integrated with microcomputers and telemetry devices. Corequisite: BME 540.
Prerequisite: BME 540.
Components: LAB.
Grading: GRD.
Typically Offered: Spring.

BME 545. Biomedical Optical Instruments. 3 Credit Hours.

Introduction to geometrical optics, light sources, detectors, and fiber optics with an emphasis on engineering aspects and medical applications. Fiber-optic d elivery systems for medical applications, optics of the eye and visual instrume nts, and optical instruments used in medicine (microscopes, endoscopes, ophthalmic instruments) are discussed. Hands-on sessions in the laboratory are included.
Prerequisite: PHY 207 and MTH 311.
Components: LEC.
Grading: GRD.
Typically Offered: Fall.

BME 546. Medical Applications of Lasers. 3 Credit Hours.

Review of geometrical optics, fiber optics, wave optics, laser physics, and technology. Medical laser systems, optical properties of tissue, light propagat ion in tissue, laser-tissue interactions, and surgical applications of lasers are also covered. Hands-on sessions in the laboratory are included.
Prerequisite: PHY 207 and MTH 311.
Components: LEC.
Grading: GRD.
Typically Offered: Spring.

BME 555. Fundamentals of Computational Neuroscience. 3 Credit Hours.

Major concepts include neural signaling and communication from the single neuro n to system of neural ensembles and the role of neural computation in engineeri ng applications. Theory and principles of information processing in the brain are presented. Experimental data and computer simulations are used to provide real examples for students experimentation.
Prerequisite: BME 265. Corequisite: BME 470.
Components: LEC.
Grading: GRD.
Typically Offered: Spring.

BME 560. Biomedical Transport Phenomena. 3 Credit Hours.

Fundamentals of transport phenomena in biological systems including diffusios, osmosis, convection, electrophoresis, and transport with binding. Applications to cell electrophysiology and drug delivery. Introduction to physiological fluid flow in tissues.
Components: LEC.
Grading: GRD.
Typically Offered: Fall & Spring.

BME 565. Principles of Cellular and Tissue Engineering. 3 Credit Hours.

Introduction to cellular and tissue engineering. Current therapeutic approaches for lost/damaged tissue or organ function, tissue engineering strategies to replace/repair tissue or function: infusion of cells, production and delivery of tissue-inducing substances, cells placed on or within biomaterial scaffolds, examples of tissue engineering applications: skin, heart muscle, blood vessels, and blood.
Prerequisite: BIL 150 and BME 335.
Components: LEC.
Grading: GRD.
Typically Offered: Fall.

BME 566. Cell and Tissue Engineering Laboratory. 1 Credit Hour.

The principles of cell and tissue engineering will be presented in a hands-on laboratory experience. General techniques learned will include sterile methods, cell culture techniques and integration of cells within biomaterials. Cell engineering topics include cell cycle/metabolism, adhesion, signal transduction, and assessment. Tissue engineering topics include fabrication, biomaterials/scaffolds and cell integration, and functional assessment.
Corequisite: BME 565.
Components: LEC.
Grading: GRD.
Typically Offered: Fall.

BME 570. Advanced Biomedical Signal Processing. 3 Credit Hours.

This course provides an overview of advanced topics in biomedical signal processing with an emphasis on practical applications. Topics include quantitative description, analysis, on-line and real-time processing of biophysical and physiological signals (cardiovascular, neural, sensory, muscular, respiratory and other) using adaptive, learning, pattern recognition and data dimension reduction methods.
Prerequisite: ECE 118 and BME 470.
Components: LEC.
Grading: GRD.
Typically Offered: Spring.

BME 571. Introduction to Biosignal Processing Lab. 1 Credit Hour.

Laboratory course in conjunction with BME 570 course. Corequisite: BME 570.
Prerequisite: BME 570. Or Corequisite: BME 570.
Components: LAB.
Grading: GRD.
Typically Offered: Fall & Spring.

BME 575. Biomechanics II. 3 Credit Hours.

Applications of linear and nonlinear viscoelastic concepts to the biomedical characteristics of biological tissues and structures at small and large deformations of blood flow, experimental methods of analysis, artificial organs, and life-support systems.
Components: LEC.
Grading: GRD.
Typically Offered: Offered by Announcement Only.

BME 581. Radiation Biology and Physics. 3 Credit Hours.

The principles, methods, and results of radiation biology with physics applications in radiation therapy will be introduced in the course. The course will focus on mechanisms of radiation and biological system interaction, biological aspects of the foundation of radiation therapy, and mathematical models for radiobiological analysis. Corequisite or pererequisite: BME 502 or permission of instructor.
Components: LEC.
Grading: GRD.
Typically Offered: Fall.

BME 582. Radiation Therapy Physics. 3 Credit Hours.

The principles and instrumentation of radiation dosimetry with focus on the applications in radiation therapy will be introduced in this course. The course will emphasize radiation dose computation algorithms and applications in treatment dose planning. The course will also cover a catagorized dosimetric analysis of radiation therapy to different clinical conditions.
Prerequisite: BME 310 and BME 581.
Components: LEC.
Grading: GRD.
Typically Offered: Spring.

BME 583. Radiation Protection. 3 Credit Hours.

This course covers radiation safety principles for all areas of clinical medical physics, including regulatory requirements for personnel, equipment and facilities and detailed structural shielding design requirements for medical facilities. The student will become proficient in practical aspects of radiation safety objectives and regulatory requirements in clinical practice, including those for patients, members of the general public and staff. Students will learn the principles for designing and installing structural shielding in clinical facilities that satisfies both regulatory requirements and clinical needs.
Components: LEC.
Grading: GRD.
Typically Offered: Fall.

BME 587. Finite Element Analysis for Engineers. 3 Credit Hours.

Introduction to the finite-element method. Hands-on applications of FEMLAB software to the analysis of structural, thermanl, chemical, electro-magnetic, optical, and fluid flow problems.
Components: LEC.
Grading: GRD.
Typically Offered: Fall & Spring.

BME 599. Cooperative Education.. 1 Credit Hour.

Practical application of classroom theory through alternating semester or summe r employment with firms offering positions consistent with the student's field of study. Course may be repeated. Periodic reports and conferences are require d.
Components: THI.
Grading: GRD.
Typically Offered: Offered by Announcement Only.

BME 601. Unified Medical Sciences I. 3 Credit Hours.

Treatment of the basic biological and medical elements in physiological systems. The anatomy, physiology, biophysics, biochemistry and certain aspects of clinical medicine are unified with an emphasis on cellular and subcellular systems. Not open to BME undergraduates.
Components: LEC.
Grading: GRD.
Typically Offered: Fall.

BME 602. Unified Medical Sciences II. 3 Credit Hours.

Treatment of the basic biological and medical elements in physiological systems . The anatomy, physiology, biophysics, biochemistry, and certain aspects of clinical medicine are unified with an emphasis on cardiovascular, renal, digestive, endocrine, and reproductive systems. Not open to BME undergraduates.
Components: LEC.
Grading: GRD.
Typically Offered: Fall.

BME 603. Unified Medical Science III. 3 Credit Hours.

Treatment of the basic biological and medical elements in physiological systems. The anatomy, physiology, biophysics, biochemistry, and certain aspects of clinical medicine are unified with an emphasis on neural, sensory, and muscular systems. Not open to BME undergraduates.
Components: LEC.
Grading: GRD.
Typically Offered: Spring.

BME 606. Computer Aided Design in Biomedical Engineering. 1 Credit Hour.

Laboratory course for computer based two and three dimensional drawing and design based on ProEngineer. Parametric design, parts, features, assemblies for complex modeling. Applications in biomedical engineering design.
Components: LAB.
Grading: GRD.
Typically Offered: Spring.

BME 607. LabView Applications for Biomedical Engineering. 1 Credit Hour.

Laboratory course for computer based instrumentation and design based on Labvie w. Virtual instrumentation, data acquisition and display, GPIB instrument contr ol, biomedical applications in biosignal recording, and monitoring are discussed.
Components: LAB.
Grading: GRD.
Typically Offered: Spring.

BME 610. Introduction to Medical Robotics. 3 Credit Hours.

This course will discuss the basic principles of robotics and focus on its medical applications. The course integrates previously learned math, programming and imaging knowledge into an application platform to enable students to understand fundamentals of robotics methods in biology and medicine and to train students to build a robotics prototype through hands-on projects.
Components: LEC.
Grading: GRD.
Typically Offered: Offered by Announcement Only.

BME 612. Regulatory Control of Biomedical Devices. 3 Credit Hours.

Regulatory agencies and requirements, Food and Drug Administration, 510(k) and premarket approval (PMA), international regulatory requirements, ISO 9000 series, CE, UL, product and process validation, quality engineering, quality improvement programs, rapid prototyping, packaging and sterilization, and project management are discussed.
Components: LEC.
Grading: GRD.
Typically Offered: Spring.

BME 620. Medical Imaging System. 3 Credit Hours.

Engineering and scientific principles of medical imaging systems. The concepts of instrumentation and diagnostic applications of different techniques and syst ems are presented. Demonstrations or exhibitions of medical systems are given i n the visits to clinic and research laboratories. Topics include digital image and image processing fundamentals, radiographic (X-ray, CT), magnetic resonance (MRI) and radio-isotopic (PET) systems, and associated image reconstruction techniques. Basic concepts and simulation of imaging systems are emphasized.
Components: LEC.
Grading: GRD.
Typically Offered: Fall.

BME 621. Medical Imaging Applications. 3 Credit Hours.

Medical applications of imaging systems and image processing techniques. Topics include image fundamentals (resolution, format, and storage), image processing fundamentals (transformation, compression, enhancement, segmentation, registration, and reconstruction), and image analysis fundamentals (calibration, quantification, correlation, linearity and depiction). Course includes dedicated computer laboratory projects and demonstrations given in clinical and research laboratories at the medical campus.Corequisite: BME 570 or equivalent.
Components: LEC.
Grading: GRD.

BME 622. Scanning Electron Microscopy in Biomedical Devices. 3 Credit Hours.

Physics and operating principles of scanning electron microscope (SEM), transmission electron microscope (TEM), and optical light microscope. Biological tissue preparation, storage, fixation and digital image storage. Each student will learn to use the SEM in the design and/or analysis of a biomedical device.
Components: LAB.
Grading: GRD.
Typically Offered: Spring.

BME 625. Special Problems. 1-3 Credit Hours.

Research and/or design projects consisting of an individual investigation of current problems. Offered by special arrangement only.
Components: THI.
Grading: GRD.
Typically Offered: Fall, Spring, & Summer.

BME 626. Special Problems. 1-3 Credit Hours.

Research and/or design projects consisting of an individual investigation of current problems. Offered by special arrangement only.
Components: LEC.
Grading: GRD.
Typically Offered: Fall & Spring.

BME 631. Technical Entrepreneurship I. 1 Credit Hour.

The first half of a two-semester sequence that simulates the work of a product development team to gain experience in technical entrepreneurship. The students propose product ideas, assess those collectively, select a few, form teams, define the product, and perform market analysis. The course is concluded with a business and technical development plan for the team's project. Lectures are presented on a variety of entrepreneurial topics.
Components: LEC.
Grading: GRD.
Typically Offered: Fall & Spring.

BME 632. Technical Entrepreneurship II. 2 Credit Hours.

The second half of a two-semester sequence that simulates the work of a product development team to gain experience in technical entrepreneurship. The students complete the development of a working prototype and refine their marketing and business plan based on experience gained during the development phase. Lectures are presented on relevant entrepreneurial topics.
Components: LEC.
Grading: GRD.
Typically Offered: Fall & Spring.

BME 635. Advanced Biomaterials. 3 Credit Hours.

Applications of biomaterials in different tissue and organ systems. Relationshi p between physical and chemical structure of materials and biological system re sponse are discussed as well as choosing, fabricating, and modifying materials for specific biomedical applications.
Components: LEC.
Grading: GRD.
Typically Offered: Offered by Announcement Only.

BME 640. Microcomputer-Based Medical Instrumentation. 3 Credit Hours.

Principles and design of microcomputer-based biomedical instruments, analog and digital signal conversion, microcomputer hardware and software design, algorithm development for medical applications, medical signal processing with microcomputers, software safety in life support systems, and current applications are discussed.
Components: LEC.
Grading: GRD.
Typically Offered: Offered by Announcement Only.

BME 641. Medical Electronic Systems Laboratory. 2 Credit Hours.

Laboratory course for BME 540. Design of medical instruments integrated with microcomputers and telemetry devices. Corequisite: BME 540.
Components: LAB.
Grading: GRD.
Typically Offered: Spring.

BME 645. Biomedical Optical Instruments. 3 Credit Hours.

Introduction to geometrical optics, light sources, detectors, and fiber optics with an emphasis on engineering aspects and medical applications. Fiber-optic d elivery systems for medical applications, optics of the eye and visual instrume nts, and optical instruments used in medicine (microscopes, endoscopes, ophthalmic instruments) are discussed. Hands-on sessions in the laboratory are included.
Components: LEC.
Grading: GRD.

BME 646. Medical Applications of Lasers. 3 Credit Hours.

Review of geometrical optics, fiber optics, wave optics, laser physics, and technology. Medical laser systems, optical properties of tissue, light propagat ion in tissue, laser-tissue interactions, and surgical applications of lasers are also covered. Hands-on sessions in the laboratory are included.
Components: LEC.
Grading: GRD.
Typically Offered: Spring.

BME 655. Fundamentals of Computational Neuroscience. 3 Credit Hours.

Major concepts include neural signaling and communication from the single neuro n to system of neural ensembles and the role of neural computation in engineeri ng applications. Theory and principles of information processing in the brain are presented. Experimental data and computer simulations are used to provide real examples for students experimentation.
Components: LEC.
Grading: GRD.
Typically Offered: Spring.

BME 660. Biomedical Transport Phenomena. 3 Credit Hours.

Fundamentals of transport phenomena in biological systems including diffusios, osmosis, convection, electrophoresis, and transport with binding. Applications to cell electrophysiology and drug delivery. Introduction to physiological fluid flow in tissues.
Components: LEC.
Grading: GRD.
Typically Offered: Fall & Spring.

BME 665. Principles of Cellular and Tissue Engineering. 3 Credit Hours.

Introduction to cellular and tissue engineering. Current therapeutic approaches for lost/damaged tissue or organ function, tissue engineering strategies to replace/repair tissue or function: infusion of cells, production and delivery of tissue-inducing substances, cells placed on or within biomaterial scaffolds, examples of tissue engineering applications: skin, heart muscle, blood vessels, and blood.
Components: LEC.
Grading: GRD.
Typically Offered: Fall.

BME 666. Cell and Tissue Engineering Laboratory. 1 Credit Hour.

The principles of cell and tissue engineering will be presented in a hands-on laboratory experience. General techniques learned will include sterile methods, cell culture techniques and integration of cells within biomaterials. Cell engineering topics include cell cycle/metabolism, adhesion, signal transduction, and assessment. Tissue engineering topics include fabrication, biomaterials/scaffolds and cell integration, and functional assessment.
Components: LEC.
Grading: GRD.
Typically Offered: Fall.

BME 670. Advanced Biomedical Signal Processing. 3 Credit Hours.

This course provides an overview of advanced topics in biomedical signal processing with an emphasis on practical applications. Topics include quantitative description, analysis, on-line and real-time processing of biophysical and physiological signals (cardiovascular, neural, sensory, muscular, respiratory and other) using adaptive, learning, pattern recognition and data dimension reduction methods.
Components: LEC.
Grading: GRD.
Typically Offered: Spring.

BME 671. Introduction to Biosignal Processing Lab. 1 Credit Hour.

Laboratory course in conjunction with BME 570 course. Corequisite: BME 570.
Components: LEC.
Grading: GRD.
Typically Offered: Fall & Spring.

BME 675. Biomechanics II. 3 Credit Hours.

Applications of linear and nonlinear viscoelastic concepts to the biomedical characteristics of biological tissues and structures at small and large deformations of blood flow, experimental methods of analysis, artificial organs, and life-support systems.
Components: LEC.
Grading: GRD.
Typically Offered: Offered by Announcement Only.

BME 681. Radiation Biology and Physics. 3 Credit Hours.

The principles, methods, and results of radiation biology with physics applications in radiation therapy will be introduced in the course. The course will focus on mechanisms of radiation and biological system interaction, biological aspects of the foundation of radiation therapy, and mathematical models for radiobiological analysis. Corequisite or pererequisite: BME 502 or permission of instructor.
Components: LEC.
Grading: GRD.
Typically Offered: Fall.

BME 682. Radiation Therapy Physics. 3 Credit Hours.

The principles and instrumentation of radiation dosimetry with focus on the applications in radiation therapy will be introduced in this course. The course will emphasize radiation dose computation algorithms and applications in treatment dose planning. The course will also cover a catagorized dosimetric analysis of radiation therapy to different clinical conditions.
Components: LEC.
Grading: GRD.
Typically Offered: Offered by Announcement Only.

BME 683. Radiation Protection. 3 Credit Hours.

This course covers radiation safety principles for all areas of clinical medical physics, including regulatory requirements for personnel, equipment and facilities and detailed structural shielding design requirements for medical facilities. The student will become proficient in practical aspects of radiation safety objectives and regulatory requirements in clinical practice, including those for patients, members of the general public and staff. Students will learn the principles for designing and installing structural shielding in clinical facilities that satisfies both regulatory requirements and clinical needs.
Components: LEC.
Grading: GRD.
Typically Offered: Offered by Announcement Only.

BME 687. Finite Element Analysis for Engineers. 3 Credit Hours.

Introduction to the finite-element method. Hands-on applications of FEMLAB software to the analysis of structural, thermanl, chemical, electro-magnetic, optical, and fluid flow problems.
Components: LEC.
Grading: GRD.
Typically Offered: Fall & Spring.

BME 699. Cooperative Education.. 1 Credit Hour.

Practical application of classroom theory through alternating semester or summer employment with firms offering positions consistent with the student's field of study. Course may be repeated. Periodic reports and conferences are required.
Components: THI.
Grading: GRD.
Typically Offered: Offered by Announcement Only.

BME 705. Master's Design Project I. 3 Credit Hours.

Comprehensive M.S. design project in biomedical engineering. Open to students i n the BS/MS and MS programs.
Components: LEC.
Grading: GRD.
Typically Offered: Fall, Spring, & Summer.

BME 706. Master's Design Project II. 3 Credit Hours.

Comprehensive M.S. design project in biomedical engineering. Open to students in the BS/MS.
Components: LEC.
Grading: GRD.
Typically Offered: Fall, Spring, & Summer.

BME 711. Accelerated Basic Science Curriculum. 1-9 Credit Hours.

Beginning in the latter part of June each year, extending to the middle of February of the ensuing year, the following accelerated and intensive complete basic science medical curriculum is offered: Embryology, Gross Anatomy, Histology, Biochemistry, Neuroanatomy, Biophysics and Neurophysiology, Systematic Physiology, Pathology, Medical Microbiology, and Pharmacology. A single grade will be entered on the graduate transcript for this course.
Components: LEC.
Grading: SUS.
Typically Offered: Fall, Spring, & Summer.

BME 713. Application of Computers in Medicine. 3 Credit Hours.

Applications in the clinical and medical research laboratories for physiological data acquisition, analysis, and management of patient records. Differences among computer systems and languages for clinical and research activities are also covered.
Components: LEC.
Grading: GRD.
Typically Offered: Offered by Announcement Only.

BME 722. Scanning Electron Microscopy Special Projects. 3 Credit Hours.

An advanced course for graduate students with basic skills in SEM. Course is open only to masters or Ph.D. students. Students will have an opportunity to do independent research under supervision of the instructor on special projects of interest that may be related to their field of study as long as it is not part of their thesis or dissertation.
Components: LEC.
Grading: GRD.
Typically Offered: Fall.

BME 723. Neural Engineering. 3 Credit Hours.

Biophysics of neural communication, quantitative electroencephalography and evoked potentials, sleep, seizure, anesthesia and intraoperative monitoring, neural stimulation, artificial and biological neural networks, cochlear and visual implants, brain and muscle stimulation.
Prerequisite: BME 503 and BME 570.
Components: LEC.
Grading: GRD.
Typically Offered: Fall & Spring.

BME 724. Neuroengineering and Neurorehabilitation. 3 Credit Hours.

Advances in Neural Engineering have led to improved medical-device designs with novel functions. This course focuses on the engineering approaches, R&D advances, and the technical principles of NeuroMotor medical implants. Neural Engineering theory and applications from the perspectives of electronics design, neural signal analysis, and neurophysiology will be covered.
Prerequisite: BME 603.
Components: LEC.
Grading: GRD.
Typically Offered: Fall.

BME 725. Special Problems. 1-3 Credit Hours.

Research and/or design projects through an individual investigation of current problems. Offered by special arrangement only.
Components: THI.
Grading: GRD.
Typically Offered: Fall, Spring, & Summer.

BME 726. Special Problems. 1-3 Credit Hours.

Research and/or design projects through an individual investigation of current problems. Offered by special arrangement only.
Components: LEC.
Grading: GRD.
Typically Offered: Fall & Spring.

BME 728. Advanced Topics. 1-3 Credit Hours.

Subject matter offerings based upon student demand and availability of faculty. Subtitles describing the topics to be offered will be shown in parentheses in the printed class schedule, following the title "Advanced Topics".
Components: LEC.
Grading: GRD.
Typically Offered: Fall & Spring.

BME 729. Advanced Medical Imaging. 3 Credit Hours.

Analysis of contemporary medical imaging systems and the associated technologies. The course focuses on principles of advanced medical imaging systems. Topics include multimodality imaging, three-dimensional image reconstruction and visualization, clinical and research applications, and derivation and comparison of algorithms.
Prerequisite: BME 520. Or Requisite: Permission of Instructor.
Components: LEC.
Grading: GRD.
Typically Offered: Spring.

BME 731. Advanced Topics. 1-3 Credit Hours.

Subject matter offerings based upon student demand and availability of faculty. Subtitles describing the topics to be offered will be shown in parentheses in the printed class schedule, following the title "Advanced Topics."
Components: LEC.
Grading: GRD.
Typically Offered: Fall & Spring.

BME 732. Advanced Topics. 1-3 Credit Hours.

Subject matter offerings based upon student demand and availability of faculty. Subtitles describing the topics to be offered will be shown in parentheses in the printed class schedule, following the title "Advanced Topics."
Components: LEC.
Grading: GRD.
Typically Offered: Fall & Spring.

BME 735. Auditory and Visual Neural Systems. 3 Credit Hours.

Design and application of auditory and visual neural systems and devices for medical purposes. Methodologies and instrumentation using electrophysiological, psychophysical and other measurements are explored focusing on diagnostic and therapeutic applications.
Prerequisite: BME 603.
Components: LEC.
Grading: GRD.
Typically Offered: Offered by Announcement Only.

BME 740. Implantable Biomedical Devices. 3 Credit Hours.

Development and advances in implantable materials and devices especially those used as electrically driven protheses. Topics include pacemakers, defibrillator s, catheters, neurological stimulators, heart assist, bone repair, and other diagnostic and therapeutic devices. The historical, medical significance, business, economic, and technical aspects of these devices and the associated instruments for monitoring are discussed. Fundamentals of electrochemical corrosion and stimulation as well the technology of implantable power sources are reviewed.
Components: LEC.
Grading: GRD.
Typically Offered: Offered by Announcement Only.

BME 745. Biomedical Optical Imaging and Diagnostics. 3 Credit Hours.

Review of geometrical optics, fiber optics, and tissue optics. Introduction to physical optics: interference, diffraction, and polarization; optical imaging resolution limits, super-resolution imaging, advanced optical microscopy, and optical coherence tomography (OCT). Imaging throughscattering tissue, imaging and diagnostics with polarized light, fluorescence, infrared, and Raman spectroscopy and applications are also discussed. Optical diagnostics using scattered light: laser Doppler flow metry, and dynamic light scattering; and opto-chemical and evanescent wave sensors are also covered.
Components: LEC.
Grading: GRD.
Typically Offered: Offered by Announcement Only.

BME 750. Advanced Biomedical Transport Phenomena. 3 Credit Hours.

Continuum mixture theory and applications to mass transport in biological tissu es, hydrogels, and other porous media. Mechano-electrochemical coupling phenome na in biological tissues and cells.
Components: LEC.
Grading: GRD.
Typically Offered: Offered by Announcement Only.

BME 760. Fundamentals of Cellular and Tissue Engineering. 3 Credit Hours.

Principles and advanced topics on cellular and tissue engineering. Topics include biodegradable and non-biodegradable biomaterials, cytokines, the traditional and stem cell-based tissue engineering approaches, bioreactors and special topics such as bone, cartilage and other tissues.
Components: LEC.
Grading: GRD.
Typically Offered: Spring.

BME 780. Biomedical Engineering Seminar. 1 Credit Hour.

Presentation of biweekly seminars by selected speakers and graduate students on current topics of interest in biomedical engineering. Attendance is required of all students registered in the PhD program.
Components: LEC.
Grading: GRD.
Typically Offered: Fall & Spring.

BME 781. Radiation Dosimetry And Physics. 3 Credit Hours.

Application of radiation physics in the field of radiation therapy. The course will cover the relevant subjects of modern physics, the basic modalities and basic instrumentations of radiation therapy, the principles of particle transport and radiation dose computation and quality assurance of radiation therapy instruments. The subject of radiation protection will also be discussed.
Prerequisite: BME 582. Or Requisite: Permission of Instructor.
Components: LEC.
Grading: GRD.
Typically Offered: Offered by Announcement Only.

BME 783. Radiation Therapy Physics Clinical Rotation. 3 Credit Hours.

Students will observe clinical activities at a designated radiation therapy center for ten hours per week. Rotation includes observation of daily treatment, simulation, dose planning, physics quality assurance and routine physics support activities (special physics consultation, weekly physics chart check, monitoring radiation safety activities, support of brachytherapy procedures). Students will meet with the course instructor one and a half hours/week to discuss the schedule and the progress of the rotation activities. Students need to submit reports on each radiation therapy category.
Prerequisite: BME 582. Or Requisite: Permission of Instructor.
Components: THI.
Grading: GRD.
Typically Offered: Offered by Announcement Only.

BME 784. Medical Physics Journal Club. 1 Credit Hour.

The course aims to keep track of recent developments in the field of Medical Physics for therapeutic and diagnostic purposes in oncology through reading, discussion and presentation of identified scientific papers from the major journals of Medical Physics among enrolled students.
Components: LEC.
Grading: GRD.
Typically Offered: Offered by Announcement Only.

BME 810. Master's Thesis. 1-6 Credit Hours.

The student working on his/her master's thesis enrolls for credit, in most departments not to exceed six, as determined by his/her advisor. Credit is not awarded until the thesis has been accepted.
Components: THI.
Grading: SUS.
Typically Offered: Fall, Spring, & Summer.

BME 820. Research in Residence. 1 Credit Hour.

Used to establish research in residence for the thesis for the master's degree after the student has enrolled for the permissible cumulative total in BME 710 (usually six credits). Credit not granted. May be regarded as full time residence.
Components: THI.
Grading: GRD.
Typically Offered: Fall, Spring, & Summer.

BME 825. Continuous Registration--Master's Study. 1 Credit Hour.

To establish residence for non-thesis master's students who are preparing for major examinations. Credit not granted. Regarded as full time residence.
Components: THI.
Grading: GRD.
Typically Offered: Fall, Spring, & Summer.

BME 830. Pre-candidacy Doctoral Dissertation. 1-12 Credit Hours.

Doctoral dissertation credits taken prior to Ph.D. student's candidacy. The stu dent will enroll for credit as determined by his/her advisor. Not more than 12 hours of BME 730 may be taken in a regular semester, nor more than six in a sum mer session.
Components: THI.
Grading: SUS.
Typically Offered: Fall, Spring, & Summer.

BME 840. Post-Candidacy Doctoral Dissertation. 1-13 Credit Hours.

Doctoral dissertation credits taken after Ph.D. student has been admitted to ca ndidacy. The student will enroll for credit as determiend by his/her advisor. N ot more than 12 credits in BME 740 may be taken in a regular semester, nor more than six credits in a summer session.
Components: THI.
Grading: SUS.
Typically Offered: Fall, Spring, & Summer.

BME 850. Research in Residence. 1 Credit Hour.

Used to establish research in residence for the Ph.D., after the student has been enrolled for the permissible cumulative total in appropriate doctoral research. Credit not granted. May be regarded as full-time residence as determined by the Dean of the Graduate School.
Components: THI.
Grading: SUS.
Typically Offered: Fall, Spring, & Summer.